Members of the charity, which formed 12 years ago, its patrons and supporters will attend the special event to be held by Prime Minister Gordon Brown on Monday, May 12.
The day is to welcome supporters of the charity into the Hall of Fame awards.
Back in 2004 Show Racism the Red Card decided to give Hall of Fame awards to their long-standing patrons and supporters, and this year the awards, which will see rugby star Joe Shaw of Newcastle Falcons become the first rugby player to join the Hall of Fame, will be held at one of the most famous addresses in the world.
Joe told
newsguardian.co.uk: "I am absolutely honoured to be the first rugby player into the Hall of Fame.
"We don't have a racist issue in our sport, and the reason I got involved was to show that you do not have to just get involved in football if that is what you think you are striving to do - there are other sports, including rugby.
"I think the idea of the project is to educate children into becoming better people through the power of sport.
"Children get tired of listening to their parents or teachers. I know that if I had had my hero spending the day with me I would try harder to listen and understand more about what they are saying.
"Some kids do not know what is right or wrong, and this project is such a positive thing to be doing with the youngsters."
Show Racism the Red Card was set up in 1995 after founder Ged Grebby got in touch with Newcastle goalkeeper Shaka Hislop regarding the charity, and he went on to become the first patron of the charity and donated the first cheque of £50.
Since then the organisation has gone from strength to strength and has offices across the UK and Europe.
Ged said: "Having Number 10 Downing Street for this year's Hall of Fame is a great coup for our organisation. We are proud of our north east roots and the fact that the campaign is now well known throughout Europe but still has its head office here on North Tyneside.
"The Hall of Fame is our way of thanking the players who have given their time so generously to make our anti-racist campaign such a success."
Former Newcastle Goalkeeper Shaka Hislop told the News Guardian: "It fills me with a lot of pride that we are at this stage and going to Downing Street."
"When I got the letter from Ged in November 1995 it was a case of a footballer earning a good living and I felt it was my responsibility to give something back to the community in a good way."
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